Repurposing Radiation Therapy for Immuno-oncology

Radiation therapy is traditionally used for the local control of tumour growth, but recent studies suggest that radiation can have immunomodulatory properties be applied in combination with immunotherapeutic agents. The paradigm using immunomodulation cancer treatment a rapidly progressing field, multiple ongoing clinical trials exploring its use immune checkpoint blockades to induce an abscopal effect. Permutations regimens, including variations dosing, planning parameters and modality, are being tested varying degrees success. relative biological effectiveness was concept introduced early days biology allows comparison across various modalities energies. Similarly, there remains need new comparing immunological modalities. In this review, we will provide overview immunobiological models preclinical monitoring regimens introduce compare screen immune-activating functions these regimens.